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Academic Journal

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 109(29):11866-11871

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Academic Journal

Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors.

Subjects: *POTASSIUM channels; *ARRHYTHMIA; *GLOBAL analysis (Mathematics)

  • Source: PLoS ONE. Feb2015, Vol. 10 Issue 2, p1-21. 21p.

  • Abstract: Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals. ... Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites ...

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Pharmacokinetic Properties of 2nd-Generation Fibroblast Growth Factor-1 Mutants for Therapeutic Application.

Subjects: *SMOKING; *CIGARETTE smokers; *CANCER patients

  • Source: PLoS ONE. Nov2012, Vol. 7 Issue 11, Special section p1-12. 12p.

  • Abstract: Fibroblast growth factor-1 (FGF-1) is an angiogenic factor with therapeutic potential for the treatment of ischemic disease. FGF-1 has low intrinsic thermostability and is characteristically ... Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites ...

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Academic Journal

The Meaning of the Elections

  • Source: The North American Review. 159(457):742-754

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Academic Journal

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.

Subjects: LONG QT syndrome treatment; POTASSIUM channels; CONTROLLED release drugs

  • Source: Proceedings of the National Academy of Sciences of the United States of America; 7/17/2012, Vol. 109 Issue 29, p11866-11871, 6p

  • Abstract: Long QT syndrome (LQTS) is a genetic disease characterized by a prolonged QT interval in an electrocardiogram (ECG), leading to higher risk of sudden cardiac ... Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and ...

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Academic Journal

Integrated Analysis of Drug-Induced Gene Expression Profiles Predicts Novel hERG Inhibitors.

Subjects: *INHIBITION of potassium channels; *GENE expression; *TARGETED drug delivery

  • Source: PLoS ONE. Jul2013, Vol. 8 Issue 7, p1-1. 1p.

  • Abstract: Growing evidence suggests that drugs interact with diverse molecular targets mediating both therapeutic and toxic effects. Prediction of these complex interactions from chemical structures alone ... Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites ...

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  • 1-8 of  8 results for ""Babcock, Joseph""